Setting the Standard

Introduced more than 30 years ago, the COBE 2991 cell processor has set the industry standard as a reliable laboratory tool for a variety of cell processing applications. It earned its enviable reputation for reliability, ease of use, instrument consistency, disposable set performance and multiapplication flexibility thanks to its many devoted users.

Showcasing Versatility

From time-tested deglycerolization procedures to bone marrow processing, the COBE 2991 cell processor has been a solid solution for a variety of procedures for washing and concentrating cellular components. Beyond the list of Terumo BCT-validated protocols, customers continue to establish new uses for the device.

Improving the Process

The COBE 2991 cell processor offers an alternative to labor-intensive methods for the separation of cell products, such as manually layering blood over a density gradient separation medium using conical tubes. These methods involve a large number of operator steps and manual pipetting techniques that require significant practice, introducing variability and the opportunity for operator error. Automated processing puts control at the user's fingertips. Protocols can be easily programmed for efficient, reproducible results while saving time and reducing the number of manual operating steps. For maximum flexibility, nearly all aspects of operation can be controlled manually. Intuitive operation saves training time, requires little technical support and reduces the opportunity for operator errors.

Simplifying With Color-Coded Tubing

The color-coded tubing on cell processing disposable sets used with the COBE 2991 cell processor enables you to easily follow a flow path, facilitating quick loading. Specialty disposable sets for bone marrow processing and other procedures allow concentration, density gradient separation and cell washing with a single disposable set.

The COBE 2991 cell processor has been used for these applications:

• Deglycerolization of previously frozen products
• Production of bone marrow concentrates
• Washing of mononuclear cells and stem cell concentrate
• Washing of blood salvaged during surgery for autologous reinfusion
• Volume reduction of cultured and expanded cell products
• Cell concentration and media exchange
• Density gradient separation
• Washing of packed red blood cells to remove plasma

Watch a cell processing procedure from start to finish

How It Works

The key features of the COBE 2991 cell processor are its centrifuge and its flexible diaphragm. When the centrifuge is spinning, the flexible diaphragm located inside the centrifuge bowl can be inflated with hydraulic fluid. As the flexible diaphragm inflates, it presses against the bottom of the cell processing bag. This gives the COBE 2991 cell processor the ability to express fluids and/or cells for removal or collection during centrifugation. The clear centrifuge cover allows you to visually observe cell separation and fluid expression.

Take It Step-by-step

Follow these basic steps for almost all cell processing procedures.

Disposables

Select the disposable tubing sets and accessories that are right for you

The tubing sets available for the COBE 2991 cell processor allow operators to focus on the protocol while enjoying the convenience and security of a single-use tubing set.

Specifications